ALERMET
Cetirizine Hydrochloride BP 10 mg

Composition: Alermet Table:

Each film coated tablet contains Cetirizine Hydrochloride BP 10 mg.

Pharmacology:

Alermet is a potent H1 receptor antagonist without any significant anticholinergic and antiserotonic effects. At pharmacologically active dose levels, it has almost no drowsiness effect and does not cause behavioral changes which may be explained by the absence of passage through the blood brain barrier. Alermet inhibits the histamine mediated early phase of the allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction. Alermet also provides a protective effect from bronchospasm induced by inhaled histamine in asthmatics. Alermet absorbs very rapidly. Plasma half-life of Cetirizine is 6.7 to 10.90 hours.

Indication:

Seasonal Allergic Rhinitis: Alermet is indicated for the relief of symptoms associated with seasonal allergic rhinitis due to allergens such as ragweed, grass and tree pollens. Symptoms treated effectively include sneezing, rhinorrhea, pruritus, ocular pruritus, tearing and redness of the eyes.

Perennial Allergic Rhinitis: Alermet is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust, mites, animal dander, and molds. Symptoms treated effectively include sneezing, rhinorrhea, post-nasal discharge, nasal pruritus, ocular pruritus and tearing.

Chronic Idiopathic Urticaria: Alermet is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria. It significantly reduces the occurrence, severity and duration of hives and significantly reduces pruritus. It is also used in allergen induced asthma.

Dosage and administration: Alermet is administered with or without food. Adults and Children 6 years and older: Alermet Tablet: 1 tablet daily.

Dosage in renal and hepatic impairment: Dosing adjustment is necessary in patients with moderate or severe renal impairment, hepatic impairment and patients on dialysis.

Contraindication: Cetirizine is contraindicated in patients who have shown hypersensitivity or idiosyncrasy to cetirizine or to its parent compound, hydroxyzine.

Warning and Precaution: Caution should be exercised when driving a car or operating a heavy machinery. Concurrent use of Cetirizine with alcohol or other CNS depressants should be avoided because additional reduction in alertness and additional impairment of CNS performance may occur.

Side effect: Cetirizine seems to cause an incidence of sedation similar to that observed with placebo and with other non-sedating antihistamines such as astemizole and terfenadine and causes a lower incidence of sedation than that with ketotifen, clemastine, pheniramine, chlorpheniramine or mequitazine. Cetirizine does not cause anticholinergic effects.

Use in pregnancy and lactation: Pregnancy category B. Cetirizine should be used in pregnancy only if clearly needed. Cetirizine has been reported to be excreted in human milk and thus, use of Cetirizine in lactating mother is not recommended.

Use in children & adolescents: In children aged 6 months to 12 years, it is commonly used to treat allergic symptoms such as rhinitis and urticaria. The recommended dose depends on age, with careful monitoring for potential side effects like drowsiness or irritability. Long-term use in children should be supervised by a healthcare professional to ensure safety and efficacy.

Drug interaction: No clinically significant interactions with theophylline, azithromycin, pseudoephedrine, ketoconazole or erythromycin and other drugs are observed.

Storage: Protect from direct light exposure. Store in dry place at a temperature not exceeding 30° C. Keep out of the reach of children.

Pack Size: Alermet Tablet: Each box contains 100’s tablets.