Composition:
Muex Syrup: Each 5 ml of syrup contains 15 mg Ambroxol Hydrochloride BP.

Pharmacology:
Muex is the active metabolite of bromhexine and it has been proven that this metabolite possesses a greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating the mechanism leading to liquefaction of mucus in the lumen of the respiratory tract, thus facilitating expectoration of mucus and reducing dyspnea. It stimulates production of phospholipids of surfactant by alveolar cells, thus contributing to the lowering of superficial tension in the alveoli. It also reduces bronchial hyperactivity. Muex has anti-inflammatory properties owing to the inhibitory effect on the production of cellular cytokines and arachidonic acid metabolites. In patients with COPD, it traditionally improves airway patency.

Indications:

• Productive cough
• Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus, including acute and chronic bronchitis
• Inflammatory disease of the rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis, and rhinitis) associated with viscid mucus
• Asthmatic bronchitis, bronchial asthma with thick expectoration
• Bronchiectasis
• Chronic pneumonia

Dosage and Administration:

• Average daily dose (preferably after a meal):
  • For children aged 2-5 years: 2.5 ml (½ teaspoon) 2 to 3 times a day.
  • For children aged 5-10 years: 5 ml (1 teaspoon) 2 to 3 times a day.
  • For individuals aged 10 years and above, including adults: 10 ml (2 teaspoons) 3 times a day.

Side effects:

• Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally.
• Rarely, allergic responses such as eruption, urticaria, or angioneurotic edema have been reported.

Contraindications:

• Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

Precautions:

• Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders.
• Patients with hepatic and renal insufficiency should take it with caution.

Drug interaction:

• Ambroxol should not be taken simultaneously with antitussives (e.g., Codeine) because phlegm, which has been liquefied by Ambroxol, might not be expectorated.

Use in Pregnancy and Lactation:

• Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the 1st trimester.
• Safety during lactation has not been established yet.

Storage:

• Protect from direct light exposure.
• Keep out of direct sunlight and at a temperature of no more than 30°C.
• Keep out of the reach of children.

Pack Size:

• Muex Syrup: Each bottle contains 100 ml syrup with a measuring cup.